Purpose of the Study: To compare the effectiveness of Muscle Energy Technique and Maitland Mobilization coupled with KIASTM in patients with periarthritis of the shoulder joint. Materials and Methods: 20 subjects with periarthritis were randomly allocated. The subjects were treated with KIASTM coupled with Muscle Energy Technique (Group I) and Maitland Mobilization (Group II). The treatment was given for 45 minutes a day up to 2 months. The outcome was measured in terms of the shoulder pain and disability index (SPADI). Results: An Independent t-test was used to compare the pre-test and post-test values between each group. On comparing the mean values of SPADI of the two groups, the study shows there is a significant increase in the post-test values of KIASTM coupled with Muscle Energy Technique than KIASTM coupled with Maitland Mobilization. Conclusion: KIASTM coupled with Muscle Energy Technique is more effective than Maitland Mobilization in reducing pain and disability, enhancing shoulder function among periarthritis subjects.