Monicah Wanjiru Mwangi, Sheilah Nangena Maina


Background: Dry eye is a serious problem affecting up to 20% of the world’s population. Mondia whitei’s rich androgenic properties create an interest in research focused on its efficacy as an alternative and complementary therapy for the treatment and control of the symptoms of dry eye-related diseases associated with androgen deficiency. Aim: This study aimed to investigate the effect of M. whitei on the quality and quantity of tears in rabbit eyes. Setting: This study was carried out at the animal house at Masinde Muliro University of Science and Technology, Kakamega, Kenya. Materials and methods: The study adopted an experimental study design with 16 New Zealand rabbits. A simple random sampling technique was used to place the rabbits into 4 groups, each group with 4 rabbits. They were tested for tear function to establish a baseline before administration of Benzalkonium Chloride (BAC) (to induce dry eye) and M. whitei extract. Schirmer’s test and fluorescein staining were conducted to observe the tear quantity and quality over a period of 6 days after treatment. The data collected was then cleaned and analyzed. Results: The researchers found that the average mean during baseline tear quantity measurement for the groups was 26.5mm, during instilling of BAC the mean dropped to 24.0mm and when M. whitei was administered the mean rose to 27.94mm, indicating that M. whitei greatly improved tear quantity. During baseline tear quality assessment, the average mean for the groups was 0.00 which dropped to 0.94 showing mild staining and when M. whitei was administered dropped further to 1.67 indicating that M. whitei did not improve the tear quality. Conclusion and Recommendations: The researchers recommended that more research be done on M. whitei with fewer limitations such as time, to ascertain its effectiveness on tear quality and quantity.


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dry eye, tear quality, tear quantity, Schirmer’s test, fluorescein staining

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DOI: http://dx.doi.org/10.46827/ejphs.v6i2.155


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