Mai Abdullah Al-Mesaibih, Sanaa Ahmed Khalifa, Afaf Hadi Hakami


The purpose of this study is to compare the effect of high cholesterol on the liver of male rabbits and rats. The experimental research methodology was used to conduct this study. The sample of study includes 12 New Zealand rabbits in adulthood at a weight of 2.5 - 3.5 kg and on 16 white rats at puberty at 130-160 gr after data were obtained from the experiments. Then, the experiment was calculated in the Standard Deviation and mean, using the Independent sample test at a time of confidence. 0.05 significant p & & p ˃ 0.05 not significant, using Statistical Package for Social Sciences (SPSS) v.21 was used for statistical analysis. Finally, the researcher came out with the following results: the animals were dissected, and the most important statistical results obtained were a significant increase in cholesterol, triglycerides, high-density proteins, low-density proteins, liver enzymes (aminotransferase and aspartate aminotransferase) in rabbits compared to rats. Significant changes were also observed in rabbits' liver compared with rat’s liver. These changes were manifested in the presence of fatty droplets in the cytoplasm of liver cells and necrosis, the deformation of the region Babiism and expansion of blood pockets and central veins.


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