PENTADECAPEPTIDE BPC 157: PANACEA OR OVERHYPED PEPTIDE?

Joseph A. Giandonato, Victor Tringali

Abstract


Interest in Pentadecapeptide BPC 157, an oligopeptide originally derived from human gastric juice, has grown substantially among members of the fitness community in the past few years due to its wide range of purported and previously reported effects on improving health and enhancing performance. In spite of these effects, the use of BPC 157 is accompanied by uncertainties, specifically the impact of long-term use. The composition, pharmacokinetics, route of administration and potential clinical applications will be presented in this brief investigative report.

 

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Keywords


BPC 157, pentadecapeptide, amino acids, injury recovery, ergogenic aids

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References


Brcic, L., Brcic, I., Staresinic, M., Novinscak, T., & Seiwerth, S. (2009). Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. Journal of Physiology and Pharmacology: An Official Journal of the Polish Phys-iological Society, 60(Suppl 7), 191-196. https://www.researchgate.net/publication/51443032_Modulatory_effect_of_gastric_pentadecapeptide_BPC_157_on_angiogenesis_in_muscle_and_tendon_healing

Chang, C.-H., Tsai, W.-C., Lin, M.-S., Hsu, Y.-H., & Pang, J.-H.S. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon out-growth, cell survival, and cell migration. Journal of Applied Physiology (1985), 110(3), 774–780. https://doi.org/10.1152/japplphysiol.00945.2010

Chang, C.-H., Tsai, W.-C., Hsu, Y.-H., & Su Pang, J.-H. (2014). Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibro-blasts. Molecules, 19(11), 19066–19077. https://doi.org/10.3390/molecules191119066

Demirtaş, H., Özer, A., Kutay Yıldırım, A., Dursun, A.D., Sezen, Ş.C., & Arslan, M. (2025). Protective effects of BPC 157 on liver, kidney, and lung distant organ damage in rats with experimental lower-extremity ischemia–reperfusion inju-ry. Medicina, 61(2), 291. https://doi.org/10.3390/medicina61020291

Đuzel, A., Vlainić, J., Antunovic, M., Malekinusic, D., Vrdoljak, B., Samara, M., Gojkovic, S., Krezic, I., Vidovic, T., Bilic, Z., Knežević, M., Sever, M., Lojo, N., Kokot, A., Kolovrat, M., Drmic, D., Vukojević, J., Kralj, T., Kasnik, K., Siroglavić, M., Seiwerth, S., & Sikiric, P. (2017). Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: new insights. World Journal of Gastroenterology, 23(48), 8465–8488. https://doi.org/10.3748/wjg.v23.i48.8465

Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protec-tion compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research, 377(2), 153–159. https://doi.org/10.1007/s00441-019-03016-8

He, L., Feng, D., Guo, H., Zhou, Y., Li, Z., Zhang, K., Zhang, W., Wang, S., Wang, Z., Hao, Q., Zhang, C., Gao, Y., Gu, J., Zhang, Y., Li, W., & Li, M. (2022). Pharmaco-kinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.1026182

Huang, T., Zhang, K., Sun, L., Xue, X., Zhang, C., Shu, Z., Mu, N., Gu, J., Zhang, W., Wang, Y., & Zhang, W. (2015). Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angio-genesis in vitro. Drug Design, Development and Therapy, 9, 2485-2499. https://doi.org/10.2147/DDDT.S82030

Józwiak, M., Bauer, M., Kamysz, W., & Kleczkowska, P. (2025). Multifunctionality and possible medical application of the BPC 157 peptide-literature and patent re-view. Pharmaceuticals (Basel), 18(2), 185. https://doi.org/10.3390/ph18020185

Perović, D., Milavic, M., Dokuzovic, S., Krezic, I., Gojkovic, S., Vranes, H., Bebek, I., Bilic, V., Somun, N., Brizic, I., Skorak, I., Hriberski, K., Sikiric, S., Lovric, E., Strbe, S., Kubat, M., Boban Blagaic, A., Skrtic, A., Seiwerth, S., & Sikiric, P. (2022). Novel therapeutic effects in rat spinal cord injuries: recovery of the definitive and early spinal cord injury by the administration of pentadecapeptide BPC 157 thera-py. Current Issues in Molecular Biology, 44(5), 1901–1927. https://doi.org/10.3390/cimb44050130

Pevec, D.R., Novinscak, T., Brcic, L., Sipos, K., Jukic, I., Staresinic, M., Mise, S., Brcic, I., Kolenc, D., Klicek, R., Banic, T., Sever, M., Kocijan, A., Berkopic, L. Radic, B., Buljat, G., Anic, T., Zoricic, I., Bojanic, I., Seiwerth, S., & Sikiric, P. (2010). Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic cortico-steroid application. Medical Science Monitor, 16(3), BR81–BR88. https://medscimonit.com/abstract/index/idArt/878454

Sikiric, P., Seiwerth, S., Grabarevic, Z., Rucman, R., Petek, M., Jagic, V., Turkovic, B., Rotkvic, I., Mise, S., Zoricic, I., Konjevoda, P., Perovic, D., Simicevic, V., Separov-ic, J., Hanzevacki, M., Ljubanovic, D., Artukovic, B., Bratulic, M., Tisljar, M., & Rekic, B. (1997). Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats. Journal of Physiology-Paris, 91(3-5), 113–122. https://doi.org/10.1016/s0928-4257(97)89474-0

Sikiric, P., Seiwerth, S., Rucman, R., Kolenc, D., Batelja Vuletic, L., Drmic, D., Grgic, T., Strbe, S., Zukanovic, G., Crvenkovic, D., Madzarac, G., Rukavina, I., Sucic, M., Baric, M., Starcevic, N., Krstonijevic, Z., Lovric Bencic, M., Filipcic, I., Stancic Ro-kotov, D., & Vlainic, J. (2016). Brain-gut Axis and pentadecapeptide BPC 157: theoretical and practical implications. Current Neuropharmacology, 14(8), 857–865. https://doi.org/10.2174/1570159x13666160502153022

Sikiric, P. Skrtic, A., Gojkovic, S., Krezic, I., Zizek, H., Lovric, E., Sikiric, S., Knezevic, M., Strbe, S., Milavic, M., Kokot, A., Boban-Blagaic, A., & Seiwerth, S. (2021). Gas-tric pentadecapeptide BPC 157 in cytoprotection to resolve major vessel occlu-sion disturbances, ischemia-reperfusion injury following Pringle maneuver, and Budd-Chiari syndrome. World Journal of Gastroenterology, 28(1), 23–46. https://doi.org/10.3748/wjg.v28.i1.23

Sikiric, P., Gojkovic, S., Krezic, I., Smoday, I.M., Kalogjera, L., Zizek, H., Oroz, K., Vranes, H., Vukovic, V., Labidi, M., Strbe, S., Baketic Oreskovic, L., Sever, M., Tepes, M., Knezevic, M., Barisic, I., Blagaic, V., Vlainic, J., Dobric, I., Staresinic, M., Skrtic, A., Jurjevic, I., Blagaic, A.B., & Seiwerth, S. (2023). Stable gastric penta-decapeptide BPC 157 may recover brain–gut axis and gut–brain axis function. Gut and Liver, 16(5), 676–676. https://doi.org/10.3390/ph16050676

Staresinic, M., Sebecic, B., Patrlj, L., Jadrijevic, S., Suknaic, S., Perovic, D., Aralica, G., Zarkovic, N., Borovic, S., Srdjak, M., Hajdarevic, K., Kopljar, M., Batelja, L., Boban-Blagaic, A., Turcic, I., Anic, T., Seiwerth, S., & Sikiric, P. (2003). Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. Journal of Orthopaedic Research, 21(6), 976–983. https://doi.org/10.1016/s0736-0266(03)00110-4

U.S. Food and Drug Administration (2024). Substances in Compounding that May Present Significant Safety Risks. https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks

Vukojević, J., Vrdoljak, B., Malekinušić, D., Siroglavić, M., Milavić, M., Kolenc, D., Boban-Blagaić, A., Batelja, L., Drmić, D., Seiverth, S., & Sikirić, P. (2020). The ef-fect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats. Brain and Behavior, 10(8). https://doi.org/10.1002/brb3.1726

Vukojević, J., Milavić, M., Perović, D., Ilić, S., Zemba Čilić, A., Đuran, N., Štrbe, S., Zoričić, Z., Filipčić, I., Brečić, P., Seiverth, S., & Sikirić, P. (2022). Pentadecapep-tide BPC 157 and the central nervous system. Neural Regeneration Research, 17(3), 482–487. https://doi.org/10.4103/1673-5374.320969




DOI: http://dx.doi.org/10.46827/ejpe.v12i9.6252

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