ARTIFICIAL INTELLIGENCE IN AUTISM SPECTRUM DISORDER: A SYSTEMATIC REVIEW OF AI-SUPPORTED SCREENING, EDUCATION, AND INTERVENTION TECHNOLOGIES

Ilias Vasileiou

Abstract


Artificial intelligence (AI) technologies are increasingly transforming research and practice in Autism Spectrum Disorder (ASD). Advances in machine learning, deep learning, computer vision, and natural language processing have enabled the development of computational tools capable of identifying behavioral markers, supporting personalized educational environments, and enhancing therapeutic interventions for individuals on the autism spectrum. Despite the rapid growth of this interdisciplinary field, the literature remains fragmented across domains including computer science, clinical medicine, psychology, and educational research. The present study provides a systematic review of empirical research examining the application of artificial intelligence technologies in autism spectrum disorder. Following the PRISMA 2020 guidelines, a comprehensive search was conducted in major international databases, including Scopus, Web of Science, PubMed, ERIC, and PsycINFO, for studies published between 2015 and 2025. After duplicate removal, screening, and eligibility assessment, 49 empirical studies were included in the final synthesis. The findings indicate that artificial intelligence applications in autism research cluster into four primary domains: AI-supported diagnostic screening and early identification, AI-based educational technologies and adaptive learning systems, socially assistive robotics for social communication training, and AI-supported therapeutic monitoring and behavioral intervention systems. Across these domains, AI technologies demonstrated promising potential to improve early detection of autism, support individualized learning environments, and enhance the effectiveness of therapeutic interventions. However, the reviewed studies also revealed substantial methodological heterogeneity, limited sample sizes, and variability in algorithmic approaches and outcome measures. In addition, ethical considerations related to data privacy, algorithmic transparency, and responsible clinical implementation remain critical challenges for the field. Overall, the evidence suggests that artificial intelligence technologies may play an increasingly important role in the future of autism screening, education, and intervention, although further interdisciplinary research and large-scale validation studies are required to ensure their reliability, effectiveness, and ethical deployment.

Keywords


artificial intelligence; autism spectrum disorder; machine learning; digital health; educational technology; systematic review

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References


Abbas, H., Garberson, F., Glover, E., & Wall, D. P. (2021). Machine learning for early detection of autism (and other conditions) using a parental questionnaire and home video screening. JMIR Pediatrics and Parenting, 4(1), e27596.

https://doi.org/10.2196/27596

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Publishing.

https://doi.org/10.1176/appi.books.9780890425596

Bone, D., Bishop, S. L., Black, M. P., Goodwin, M. S., Lord, C., & Narayanan, S. (2016). Use of machine learning to improve autism screening and diagnostic instruments: Effectiveness, efficiency, and multi-instrument fusion. Journal of Child Psychology and Psychiatry, 57(8), 927–937.

https://doi.org/10.1111/jcpp.12559

Daniels, A. M., & Mandell, D. S. (2014). Explaining differences in age at autism spectrum disorder diagnosis. Journal of the American Academy of Child & Adolescent Psychiatry, 53(6), 583–590.

https://doi.org/10.1016/j.jaac.2014.02.002

Dawson, G., Rogers, S., Munson, J., Smith, M., Winter, J., Greenson, J., Donaldson, A., & Varley, J. (2010). Randomized, controlled trial of an intervention for toddlers with autism: The Early Start Denver Model. Pediatrics, 125(1), e17–e23.

https://doi.org/10.1542/peds.2009-0958

Diehl, J. J., Schmitt, L. M., Villano, M., & Crowell, C. R. (2012). The clinical use of robots for individuals with autism spectrum disorders: A critical review. Research in Autism Spectrum Disorders, 6(1), 249–262.

https://doi.org/10.1016/j.rasd.2011.05.006

Duda, M., Kosmicki, J., & Wall, D. P. (2016). Testing the accuracy of an observation-based classifier for rapid detection of autism risk. Translational Psychiatry, 6, e776.

https://doi.org/10.1038/tp.2016.41

Eslami, T., Mirjalili, V., Fong, A., Laird, A. R., & Saeed, F. (2019). ASD-DiagNet: A hybrid learning approach for detection of autism spectrum disorder using fMRI data. Frontiers in Neuroinformatics, 13, 70.

https://doi.org/10.3389/fninf.2019.00070

Estes, A., Munson, J., Rogers, S. J., Greenson, J., Winter, J., & Dawson, G. (2015). Long-term outcomes of early intervention in 6-year-old children with autism spectrum disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 54(7), 580–587. https://doi.org/10.1016/j.jaac.2015.04.005

Floridi, L., Cowls, J., Beltrametti, M., Chatila, R., Chazerand, P., Dignum, V., Luetge, C., Madelin, R., Pagallo, U., Rossi, F., & Schafer, B. (2018). AI4People—An ethical framework for a good AI society. Minds and Machines, 28(4), 689–707.

https://doi.org/10.1007/s11023-018-9482-5

Florian, L., & Black-Hawkins, K. (2011). Exploring inclusive pedagogy. Cambridge Journal of Education, 41(4), 429–445.

https://doi.org/10.1080/0305764X.2011.625076

Hehir, T., Grindal, T., Freeman, B., Lamoreau, R., Borquaye, Y., & Burke, S. (2016). A summary of the evidence on inclusive education. Alana Institute.

https://doi.org/10.13140/RG.2.2.13440.46086

Holmes, W., Bialik, M., & Fadel, C. (2019). Artificial intelligence in education: Promises and implications for teaching and learning. Center for Curriculum Redesign.

https://doi.org/10.13140/RG.2.2.22626.45763

Ke, F., & Im, T. (2013). Virtual-reality-based social interaction training for children with high-functioning autism. Journal of Educational Research, 106(6), 441–461.

https://doi.org/10.1080/00220671.2013.832999

Khowaja, K., Salim, S. S., & Zakaria, M. H. (2020). The use of digital games for social skills development in children with autism spectrum disorder: A systematic literature review. IEEE Access, 8, 16537–16553.

https://doi.org/10.1109/ACCESS.2020.2968514

Kitchenham, B., & Charters, S. (2007). Guidelines for performing systematic literature reviews in software engineering. Keele University. Retrieved from https://www.researchgate.net/publication/302924724_Guidelines_for_performing_Systematic_Literature_Reviews_in_Software_Engineering

Lord, C., Brugha, T., Charman, T., Cusack, J., Dumas, G., Frazier, T., Jones, E., Jones, R., Pickles, A., State, M., Taylor, J., & Veenstra-VanderWeele, J. (2020). Autism spectrum disorder. Nature Reviews Disease Primers, 6, 5.

https://doi.org/10.1038/s41572-019-0138-4

Luckin, R., Holmes, W., Griffiths, M., & Forcier, L. (2016). Intelligence unleashed: An argument for AI in education. Pearson.

https://doi.org/10.13140/RG.2.2.10131.94246

Maenner, M. J., Shaw, K. A., Bakian, A. V., Bilder, D. A., Durkin, M. S., Esler, A., Furnier, S. M., Hall-Lande, J., Hallas, L., Hudson, A., Hughes, M., Patrick, M., Pierce, K., Poynter, J., Salinas, A., Shenouda, J., Vehorn, A., Warren, Z., & Constantino, J. (2023). Prevalence and characteristics of autism spectrum disorder among children aged 8 years. MMWR Surveillance Summaries, 72(2), 1–14.

https://doi.org/10.15585/mmwr.ss7202a1

Odom, S. L., Thompson, J. L., Hedges, S., Boyd, B., Dykstra, J., Duda, M., Szidon, K., Smith, L., & Bord, A. (2015). Technology-aided interventions and instruction for adolescents with autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(12), 3805–3819.

https://doi.org/10.1007/s10803-014-2320-6

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T., Mulrow, C., Shamseer, L., Tetzlaff, J., Akl, E., Brennan, S., Chou, R., Glanville, J., Grimshaw, J., Hróbjartsson, A., Lalu, M., Li, T., Loder, E., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71.

https://doi.org/10.1136/bmj.n71

Parsons, S., & Cobb, S. (2011). State-of-the-art of virtual reality technologies for children on the autism spectrum. European Journal of Special Needs Education, 26(3), 355–366.

https://doi.org/10.1080/08856257.2011.593831

Pennisi, P., Tonacci, A., Tartarisco, G., Billeci, L., Ruta, L., Gangemi, S., & Pioggia, G. (2016). Autism and social robotics: A systematic review. Autism Research, 9(2), 165–183. https://doi.org/10.1002/aur.1527

Popay, J., Roberts, H., Sowden, A., Petticrew, M., Arai, L., Rodgers, M., Britten, N., Roen, K., & Duffy, S. (2006). Guidance on the conduct of narrative synthesis in systematic reviews. Lancaster University.

Scassellati, B., Admoni, H., & Matarić, M. (2018). Robots for use in autism research. Annual Review of Biomedical Engineering, 20, 275–294.

https://doi.org/10.1146/annurev-bioeng-062117-121146

Thabtah, F. (2019). Machine learning in autistic spectrum disorder behavioral research. Informatics for Health and Social Care, 44(1), 1–15.

https://doi.org/10.1080/17538157.2017.1399132

Topol, E. (2019). Deep medicine: How artificial intelligence can make healthcare human again. Basic Books. Retrieved from https://dl.acm.org/doi/10.5555/3350442

Washington, P., Kosmicki, J., Srivastava, P., Thurlow, B., Torres, A., & Wall, D. P. (2020). Precision telemedicine through crowdsourced machine learning: Testing variability of crowd workers for video-based autism feature recognition. Journal of Personalized Medicine, 10(3), 86.

https://doi.org/10.3390/jpm10030086

Zeidan, J., Fombonne, E., Scorah, J., Ibrahim, A., Durkin, M., Saxena, S., Yusuf, A., Shih, A., & Elsabbagh, M. (2022). Global prevalence of autism: A systematic review update. Autism Research, 15(5), 778–790.

https://doi.org/10.1002/aur.2696




DOI: http://dx.doi.org/10.46827/ejse.v12i5.6741

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